Usher has revealed plans to perform a "ladies only" circuit at sexual venues.
Explaining wherefore he wants to perform for women only, Usher said: "There's only a few artists that tin can pull that off.
"I feel like I've had such a connecter with my audience. This album, I felt like, was decidedly the type of one that was more informal.
"So what better way to come up shut and personal than to make it all women?"
The R&B principal will perform 15 gigs on his 'One Night Stand' junket, according to the Associated Press.
He added: "The ladies like to see that masculine build. They question if I still got it."
More information
Sunday, 7 September 2008
Monday, 18 August 2008
How Tumor Suppress Or Inhibits Cell Growth
�Genes that inhibit the spontaneous development of genus Cancer are called tumor suppressor genes. One of the major neoplasm suppressors is p53, a protein that acts in the cell nucleus to control the expression of other genes whose products can bottle up cell proliferation (increase in cell number) and cell growth (increase in jail cell size). Abnormal cell proliferation and growth are characteristics of cancer the Crab. Scientists previously knew which p53 butt genes stamp down cell proliferation, but those required for inhibition of cell growth were unknown.
New work by researchers at the University of California, San Diego School of Medicine describes the mechanism by which p53 regulates cells and protects them against DNA damage that might pb to crab. The sketch shows that two p53 target genes called Sestrin1 and Sestrin2 provide an important contact between p53 and a protein kinase called mTOR, a central regulator of cell growth. mTOR is the object for the inhibitory activeness of the immunosuppressive drug rapamycin, of late found to have antineoplastic activity.
The discovery by Michael Karin, Ph.D., professor of pharmacology in the Laboratory of Gene Regulation and Signal Transduction at the UC San Diego School of Medicine, and postdoctoral research fellow Andrei V. Budanov, Ph.D, will be published in the August 8 way out of the journal Cell.
"The two Sestrin genes appear to be the missing piece of the mystifier that explains how p53 can inhibit the mTOR pathway and thereby negatively regulate cell growth," aforesaid Budanov, wHO added that while the connection 'tween the deuce was known, the mechanism wasn't previously understood. The finding english hawthorn prove to be very important in scientists' search for novel inhibitors that stop or slow cancer tumor growth.
In fact, Budanov obtained results suggesting that the two Sestrins whitethorn be tumour suppressors in their have right. DNA damage (genotoxic stress) triggers two major biological responses in mammals: cell oscillation arrest, which allows repair and survival of the cell; and apoptosis or cell death a sue in which damaged cells, which could otherwise pass on rise to cancer, ar eliminated.
The major tumor suppresser p53 can either inhibit cell proliferation and cubicle growth or induce cell death; its different functions are mediated through numerous target genes and reckon on the extent of damage to the cellphone. As more than than half of human cancers either lost p53 expression or express a defective edition of p53, understanding the mechanisms by which p53 accomplishes its critical tumour suppressive function may lead to development of modern cancer preventives and therapeutics.
The UCSD researchers wondered what target genes would grant p53 to inhibit mobile phone growth. The central regulator of cell growth is the protein kinase mTOR, whose activity is inhibited by rapamycin, which is used in prevention of organ transplant rejection. Recent work indicates that rapamycin may besides be used to inhibit the growth of tumors and give them more susceptible to chemotherapy.
Previous studies conducted by Budanov showed that the Sestrin1 and Sestrin2 proteins, which are expressed in response to genotoxic stress, serve a protective single-valued function and may also curb cell growth. It has also been shown that Sestrin1 and 2, as well as their master regulator p53, can restraint the accumulation of reactive oxygen species (ROS), which play of import roles in cell signaling. Under genotoxic stress, ROS levels can increase dramatically, which can lead to significant damage to cell structures, resulting in oxidative stress.
"We have now shown that in addition to controlling ROS accumulation, Sestrins and p53 also inhibit cell growth by inhibiting the activity of mTOR. This explains how p53 functions as a potent regulator of so many aspects of cell physiology and provides protection against DNA wrong and tension," said Budanov.
Knockout mouse models of Sestrin1 and 2 will be an important tool for studying their role in carcinogenesis, according to the researchers. Karin adds that small molecules that mimicker the molecular actions of the Sestrins can be used to control cell metabolism and regain control over malignant neoplastic disease cells that have lost their p53.
Funding for this study was provided by grants from the Tobacco Related Disease Research Program, the National Institute of Environmental Health Science and the Superfund Basic Research Program.
University of California, San Diego
University Communications, 0938 9500 Gilman Dr.
LaJolla, CA 92093
United States
http://www.ucsd.edu
More info
New work by researchers at the University of California, San Diego School of Medicine describes the mechanism by which p53 regulates cells and protects them against DNA damage that might pb to crab. The sketch shows that two p53 target genes called Sestrin1 and Sestrin2 provide an important contact between p53 and a protein kinase called mTOR, a central regulator of cell growth. mTOR is the object for the inhibitory activeness of the immunosuppressive drug rapamycin, of late found to have antineoplastic activity.
The discovery by Michael Karin, Ph.D., professor of pharmacology in the Laboratory of Gene Regulation and Signal Transduction at the UC San Diego School of Medicine, and postdoctoral research fellow Andrei V. Budanov, Ph.D, will be published in the August 8 way out of the journal Cell.
"The two Sestrin genes appear to be the missing piece of the mystifier that explains how p53 can inhibit the mTOR pathway and thereby negatively regulate cell growth," aforesaid Budanov, wHO added that while the connection 'tween the deuce was known, the mechanism wasn't previously understood. The finding english hawthorn prove to be very important in scientists' search for novel inhibitors that stop or slow cancer tumor growth.
In fact, Budanov obtained results suggesting that the two Sestrins whitethorn be tumour suppressors in their have right. DNA damage (genotoxic stress) triggers two major biological responses in mammals: cell oscillation arrest, which allows repair and survival of the cell; and apoptosis or cell death a sue in which damaged cells, which could otherwise pass on rise to cancer, ar eliminated.
The major tumor suppresser p53 can either inhibit cell proliferation and cubicle growth or induce cell death; its different functions are mediated through numerous target genes and reckon on the extent of damage to the cellphone. As more than than half of human cancers either lost p53 expression or express a defective edition of p53, understanding the mechanisms by which p53 accomplishes its critical tumour suppressive function may lead to development of modern cancer preventives and therapeutics.
The UCSD researchers wondered what target genes would grant p53 to inhibit mobile phone growth. The central regulator of cell growth is the protein kinase mTOR, whose activity is inhibited by rapamycin, which is used in prevention of organ transplant rejection. Recent work indicates that rapamycin may besides be used to inhibit the growth of tumors and give them more susceptible to chemotherapy.
Previous studies conducted by Budanov showed that the Sestrin1 and Sestrin2 proteins, which are expressed in response to genotoxic stress, serve a protective single-valued function and may also curb cell growth. It has also been shown that Sestrin1 and 2, as well as their master regulator p53, can restraint the accumulation of reactive oxygen species (ROS), which play of import roles in cell signaling. Under genotoxic stress, ROS levels can increase dramatically, which can lead to significant damage to cell structures, resulting in oxidative stress.
"We have now shown that in addition to controlling ROS accumulation, Sestrins and p53 also inhibit cell growth by inhibiting the activity of mTOR. This explains how p53 functions as a potent regulator of so many aspects of cell physiology and provides protection against DNA wrong and tension," said Budanov.
Knockout mouse models of Sestrin1 and 2 will be an important tool for studying their role in carcinogenesis, according to the researchers. Karin adds that small molecules that mimicker the molecular actions of the Sestrins can be used to control cell metabolism and regain control over malignant neoplastic disease cells that have lost their p53.
Funding for this study was provided by grants from the Tobacco Related Disease Research Program, the National Institute of Environmental Health Science and the Superfund Basic Research Program.
University of California, San Diego
University Communications, 0938 9500 Gilman Dr.
LaJolla, CA 92093
United States
http://www.ucsd.edu
More info
Friday, 8 August 2008
Tom De Neef
Artist: Tom De Neef
Genre(s):
Electronic
Trance
Discography:
Adobe
Year: 2006
Tracks: 2
Mme Butterfly
Year: 2005
Tracks: 3
Sniper
Wednesday, 11 June 2008
Summer TV shows on tap
Here's a list of new summer series and returning favorites.
New
Sundays: "In Plain Sight" (10 p.m., USA). Mary McCormack ("The West Wing") stars as a marshal for the witness-protection program.
Thursdays: "Swingtown" (10 p.m., CBS) revisits the 1970s and the heyday of wife-swapping and adulterous exhibitionism.
June 18: "Black Gold" (10 p.m., TruTV) follows the tough-guy genre to the world of oil fields and wildcatters. From the makers of "Ice Road Truckers," "Deadliest Catch" and "Ax Men."
June 29: "The Factory" (10 p.m., Spike) offers a blue-collar variation on "The Office," following four characters working (and avoiding work) at a drab, small-town assembly-line job.
Returning
Sundays: "Army Wives" (10 p.m., Lifetime) ended its first season with a bomb on the base and the perfect cliffhanger.
June 16: "Weeds" (10 p.m., Showtime), considered smart by some, smug by others and habit-forming by many, enters its fourth season.
July 10: "Burn Notice" (10 p.m., USA). A spy on the lam survives on wit, sex appeal, charm and his ability to MacGyver his way out of situations.
July 14: "The Closer" (9 p.m., TNT). Kyra Sedgwick as a detective from Georgia who joins an L.A. police unit that solves high-profile murder cases.
See Also
Friday, 6 June 2008
Village People
Artist: Village People
Genre(s):
Other
disco
Discography:
Collection (Fake)
Year: 2002
Tracks: 12
Sex Over The Phone
Year: 1985
Tracks: 8
In The Street
Year: 1983
Tracks: 9
San Francisco and Macho Man
Year: 1979
Tracks: 9
Go West
Year: 1979
Tracks: 6
Go West_In The Navy
Year: 1978
Tracks: 6
Cruisin'
Year: 1978
Tracks: 6
Part cagy concept, part overstated camp represent, the Village People were world-wide sensations during disco's flower and prevent revitalising like the capital of Arizona. Producer Jacques Morali in 1977 assembled a group intentional to attract merry audiences spell parodying (some claimed exploiting) that same constituency's stereotypes. Songwriters Phil Hurtt and Peter Whitehead were tabbed to compose songs with gay underpinnings, and roles and costumes were cautiously selected; among them were a cowboy, biker, soldier, police officer, and twist worker nail with tough hat. The group clicked start in England with the individual "San Francisco (You Got Me)" in 1977, then reaped stateside honors with "Macho Man" in 1978. "Y.M.C.A." and "In the Navy" were planetary smashes, both peaking at number deuce on the crop up charts. After iI more than successful singles, "Go West" and "Can't Stop the Music," the group's fortunes plummeted, in big piece due to their involution in the ill-fated photographic film besides coroneted Can't Stop the Music.
Thursday, 29 May 2008
Carolina Choclate Drops thrill Blues Tent
The great Thursday afternoon revelation for me and a couple thousand other smitten new fans in the Southern Comfort Blues Ten were the Carolina Chocolate Drops. By definition, they are revivalists, revisiting rural African-American folk songs from as far back...
Friday, 23 May 2008
FADER Media and RCRD LBL Join Forces to Offer Marketers Compelling Sponsorship Packages, Access to Powerful Audience
FADER Media and RCRD LBL Join Forces to Offer Marketers Compelling Sponsorship Packages, Access to Powerful Audience
FADER to Treat Sponsorship and Ad for High profile Online Music
Network RCRD LBL
Newly House of York, Apr 15 -- The FADER, the definitive voice of
emerging music, today announced that RCRD LBL will be represented by the
company's FADER Media network. Under this agreement, FADER Media will be
treatment advert gross revenue and buy at development for RCRD LBL, the low
online euphony label oblation unloose, sponsor-supported MP3s from established
and emerging artists and labels crosswise a change of niches and genres. With
the joining of the deuce, brands and marketers give birth a mighty opportunity to
accomplish one of the nearly coveted and culturally relevant demographics in
young oriented, online music lovers. FADER Media VP and Grouping Publisher
Andy Ferdinand Julius Cohn and St. Peter Rojas Chief executive officer, RCRD LBL made the announcement.
FADER Media comprises creative properties including photographic print, online,
radio, events, a music label, film and television receiver divisions-all dedicated
to emerging natural endowment across medicine and culture. In accession to RCRD LBL, this
includes FADER online and print; theTripwire.com, a music site for those
interested in exploring the indie/alternative music setting and modus vivendi;
the 1200 Squad (1200Squad.com), a rap music music situation known for its unique
ability to provide top DJs with the hottest music and exclusive lifestyle
products-before they strike the market; The FADER Tag and FADER Films, with
additional properties organism created and acquired.
RCRD LBL launched in Nov 2007 with Cougar, airline Virgo the Virgin America
and Nikon Iraqi National Congress. among the major brands that signed on as inauguration sponsors.
"RCRD LBL is a cancel married person for us and a great asset for us to bring
to our forward-thinking ad nucleotide," says Cohn. "Piece they share a
very similar esthetic with our stream properties, the functionality of
their situation in lawfully delivering curated music to consumers for release is
completely different from our other properties. Their innovative mindset
and revolutionary clientele theoretical account fit perfectly in line with The FADER."
"The FADER crew instinctively get what we're trying to do with RCRD
LBL, on that point ar few others I'd trust to constitute us. They understand that
our unique ad-supported modeling doesn't precisely command great music, it needs
forward intellection brands that interpret a unique opportunity to link up with
tastemaking audiences in a cool, credible way," said Rojas.
Roughly RCRD LBL
RCRD LBL is a blog-driven destination that offers artists an
opportunity to link with brigham Young audiences world Health Organization are progressively
discovering and sharing music on-line. At the saame fourth dimension, the online label
provides sponsors and publicizing partners with a mightily freshly way to turn over
this influential audience of passionate euphony consumers. RCRD LBL is a
stick venture 'tween Downtown Records, which has released hits from such
acclaimed acts as Gnarls Alben Barkley and Coldness Warfare Kids, and Rojas, world Health Organization founded
the popular online community Engadget and as well serves as the site's
editorial manager.
Around Business district RECORDS
Downtown Records is an mugwump record label and music publishing
company formed in 2006. The company's roster includes Grammy winners Gnarls
Alben William Barkley, Coldness War Kids, Spank Rock candy, Justice, Kevin Michael, Eagles of Death
Alloy, Artistry Brut and others. Downtown Medicine Publication owns or controls over
1,000 titles recorded by artists including Aretha Franklin, Blessed Virgin J. Blige,
50 Cent, Hannah Montana's Miley Cyrus the Younger and the cast of High School Musical comedy
2. The company besides represents writer/artists signed to Business district Records
such as Cold State of war Kids, Carla Bruni and Kevin Michael. Business district is likewise a
joint venture partner in RCRD LBL, an online, totally ad-supported digital
music label which offers free downloads in a blog format.
About FADER MEDIA
Headquartered in Freshly York, FADER Media is comprised of mark, online,
receiving set, events, a music label, film and goggle box dedicated to emerging
talent across music and culture. Including FADER online and print,
theTripwire.com, 1200 Squad, the FADER Label, and FADER Films, FADER Media
offers brand partners access to cross-platform outlets across a wide-array
of media properties.
Tony Moran
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